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In vitro glucocorticosteroid and mineralocorticosteroid biosynthesis in Conn's adenoma tissues.

Abstract
The in vitro metabolism of [1,2-3H] deoxycorticosterone (DOC), [1,2-3H] 18-hydroxy-11-deoxycorticosterone (18-OHDOC) and [1,2-3H] 11-deoxycortisol (S) was studied in adrenal adenoma homogenates from patients with primary hyperaldosteronism. Tumor tissues actively converted deoxycorticosterone and 18-hydroxy-11-deoxycorticosterone to 18-hydroxycorticosterone and aldosterone. Yields of cortisol and cortisone were also large showing that the tissues did not lack the zona fasciculata-like 11 beta-hydroxylation ability.
AuthorsA Bogdan, A Auzéby, P F Plouin, Y Touitou
JournalJournal of endocrinological investigation (J Endocrinol Invest) Vol. 16 Issue 1 Pg. 65-8 (Jan 1993) ISSN: 0391-4097 [Print] Italy
PMID8445158 (Publication Type: Journal Article)
Chemical References
  • 18-Hydroxydesoxycorticosterone
  • Glucocorticoids
  • Mineralocorticoids
  • Desoxycorticosterone
  • Aldosterone
  • 18-Hydroxycorticosterone
  • Cortisone
  • Cortodoxone
  • Hydrocortisone
Topics
  • 18-Hydroxycorticosterone (metabolism)
  • 18-Hydroxydesoxycorticosterone (metabolism)
  • Adenoma (metabolism)
  • Adrenal Gland Neoplasms (metabolism)
  • Aldosterone (biosynthesis)
  • Cortisone (biosynthesis)
  • Cortodoxone (metabolism)
  • Desoxycorticosterone (metabolism)
  • Female
  • Glucocorticoids (biosynthesis)
  • Humans
  • Hydrocortisone (biosynthesis)
  • Hyperaldosteronism (metabolism)
  • Male
  • Mineralocorticoids (biosynthesis)

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