Abstract |
Eight controlled trials were conducted, using 96 cattle of European breeds, to evaluate the efficacy of abamectin against natural and artificially acquired infections of adult and fourth-stage larvae of all the economically important gastrointestinal nematodes and lungworms in Germany and the United Kingdom. Half the animals were treated on one occasion with abamectin at a dose of 200 micrograms/kg bodyweight given subcutaneously while the other half remained untreated. Worms were counted 14 or 21 days after treatment or 28 days after the last infection. The treatment was highly effective (> 99 to 100 per cent) (P < 0.05) at removing immature (L4) stages and adult worms of the following species: Ostertagia ostertagi (inhibited larvae included), Trichostrongylus axei, Haemonchus contortus, Bunostomum phlebotomum, Cooperia species Oesophagostomum radiatum and Dictyocaulus viviparus. Naturally acquired adult C surnabada and Trichuris discolor infections were also significantly (P < 0.05) reduced. For Nematodirus helvetianus the efficacy varied from 89.8 to > 99 per cent (P > 0.1 to < 0.01). Abamectin gave full protection against the gastrointestinal nematodes O ostertagi, H contortus, Cooperia species and O radiatum for at least seven days and against the lungworm D viviparus for at least 14 days after treatment.
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Authors | E M Heinze-Mutz, S R Pitt, K Bairden, D G Baggott, J Armour, D Barth, L G Cramer |
Journal | The Veterinary record
(Vet Rec)
Vol. 132
Issue 2
Pg. 35-7
(Jan 09 1993)
ISSN: 0042-4900 [Print] England |
PMID | 8442334
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anthelmintics
- abamectin
- Ivermectin
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Topics |
- Animals
- Anthelmintics
(therapeutic use)
- Cattle
- Cattle Diseases
(drug therapy, prevention & control)
- Dictyocaulus Infections
(drug therapy, prevention & control)
- Female
- Intestinal Diseases, Parasitic
(drug therapy, prevention & control, veterinary)
- Ivermectin
(analogs & derivatives, therapeutic use)
- Male
- Nematode Infections
(drug therapy, prevention & control, veterinary)
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