Abstract | OBJECTIVES: DESIGN: This experimental study was performed in chronically instrumented conscious dogs and at equipotent cyanide antidotal doses ( hydroxocobalamin 70 mg.kg-1; cobalt edetate 10.5 mg.kg-1). RESULTS: Peak plasma cobalt concentrations did not differ in the two groups (412 +/- 183 vs 400 +/- 160 mumol.l-1). Hydroxocobalamin induced a slight increase in mean arterial pressure (+17 +/- 9%, p < 0.05) and systemic resistance (+19 +/- 15%, p < 0.05). In contrast, cobalt edetate induced an increase in heart rate (+78 +/- 33%, p < 0.05), in cardiac output (+63 +/- 39%, p < 0.05), and in maximum rise of left ventricular pressure (+33 +/- 15%, p < 0.05), did not modify mean arterial pressure, and decreased systemic resistance (-36 +/- 15%, p < 0.05). These hemodynamic effects were associated with an increase in plasma catecholamine concentrations ( epinephrine: 2524 +/- 3025 vs. 58 +/- 37 pg.ml-1, p < 0.05; norepinephrine: 1106 +/- 609 vs. 343 +/- 146 pg.ml-1, p < 0.05), which in contrast remained unchanged after hydroxocobalamin administration. Cobalt edetate also induced an increase in blood glucose concentrations (9.9 +/- 1.9 vs. 6.1 +/- 1.2 mmol.l-1, p < 0.05) and a moderate metabolic acidosis, whereas hydroxocobalamin did not. After adrenergic (alpha 1, beta) and cholinergic receptor blockade, cobalt edetate did not modify heart rate and various indices of cardiac function, suggesting that it has no direct cardiac effects. CONCLUSION:
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Authors | B Riou, A Berdeaux, E Pussard, J F Giudicelli |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 19
Issue 1
Pg. 26-32
( 1993)
ISSN: 0342-4642 [Print] United States |
PMID | 8440794
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Atropine Derivatives
- Catecholamines
- Cyanides
- Parasympatholytics
- Cobalt
- methylatropine
- Propranolol
- Hydroxocobalamin
- Prazosin
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Topics |
- Animals
- Atropine Derivatives
(pharmacology)
- Catecholamines
(blood)
- Cobalt
(blood, pharmacology)
- Cyanides
(antagonists & inhibitors)
- Dogs
- Female
- Heart
(drug effects)
- Hemodynamics
(drug effects)
- Hydroxocobalamin
(pharmacology)
- Male
- Parasympatholytics
(pharmacology)
- Prazosin
(pharmacology)
- Propranolol
(pharmacology)
|