Abstract |
The case history, laboratory findings and clinical course of a patient with pure red cell aplasia (PRCA) combined with myasthenia gravis and thymoma are reported herein. In vitro study revealed bilineage complement-dependent IgG inhibitor(s) in both the granulocyte-macrophage and erythroblastic progenitor cells. His serum showed high anti- acetylcholine receptor antibody levels associated with activity of myasthenia gravis as well as PRCA. Patient history of thymectomy 7 years previously followed by extensive cutaneous candidiasis with abnormal T lymphocyte subsets (decreased T4/T8 ratio and increased number of activated T lymphocytes) in both the bone marrow and peripheral blood suggested primary T lymphocyte dysfunction, whereas the erythropoiesis was not inhibited by T lymphocytes. This case is of interest in the context of a possible immunological pathogenesis for other hematopoietic disorders, including some cases of aplastic anemia.
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Authors | T Murase |
Journal | Experimental hematology
(Exp Hematol)
Vol. 21
Issue 3
Pg. 451-5
(Mar 1993)
ISSN: 0301-472X [Print] Netherlands |
PMID | 8440342
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antibodies
- Antibodies, Monoclonal
- Immunoglobulin G
- Receptors, Cholinergic
- Complement System Proteins
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Topics |
- Antibodies
(blood)
- Antibodies, Monoclonal
(analysis, immunology)
- CD4-CD8 Ratio
- Complement System Proteins
(physiology)
- Flow Cytometry
- Granulocytes
(cytology)
- Hematopoiesis
(physiology)
- Hematopoietic Stem Cells
(drug effects)
- Humans
- Immunoglobulin G
(analysis)
- Macrophages
(cytology)
- Male
- Middle Aged
- Myasthenia Gravis
(complications, pathology, physiopathology)
- Receptors, Cholinergic
(analysis, immunology)
- Red-Cell Aplasia, Pure
(complications, pathology, physiopathology)
- Stem Cells
(drug effects)
- T-Lymphocyte Subsets
(immunology, pathology, physiology)
- T-Lymphocytes
(pathology, physiology, ultrastructure)
- Thymoma
(complications, pathology, physiopathology)
- Thymus Neoplasms
(complications, pathology, physiopathology)
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