Use of carbon-11 acetate and dynamic positron emission tomography to assess regional myocardial oxygen consumption in patients with acute myocardial infarction receiving thrombolysis or coronary angioplasty.

Abstract

Carbon-11 (C-11) acetate has been introduced for the noninvasive measurements of myocardial oxygen consumption. This study was designed to assess regional C-11 acetate clearance in patients with acute myocardial infarction. Thirty-one patients were studied within 8 days of acute myocardial infarction. C-11 acetate washout-rate constants were significantly lower in the infarct territory than in the remote myocardium (p < 0.008). The scintigraphic measurements correlated with heart rate-blood pressure product in the remote as well as infarct areas (0.52 and 0.48, respectively). There was no significant correlation to left ventricular ejection fraction. C-11 washout rates were significantly affected by beta-receptor therapy as assessed by multiple regression analysis. Thus, C-11 acetate kinetics allow noninvasive characterization of regional myocardial oxygen demand, which may be useful in assessing the extent of myocardial injury and myocardial oxygen demand of remote myocardium.

• Authors: V Kalff, R J Hicks, G Hutchins, E Topol, M Schwaiger
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 71 Issue 7 Pg. 529-35 (Mar 01 1993) ISSN: 0002-9149 [Print] United States
• PMID: 8438738 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carbon Radioisotopes

Topics

• Adult
• Aged
• Angioplasty, Balloon, Coronary
• Blood Pressure (physiology)
• Carbon Radioisotopes
• Female
• Humans
• Image Processing, Computer-Assisted
• Male
• Middle Aged
• Myocardial Infarction (diagnostic imaging, metabolism, therapy)
• Observer Variation
• Oxygen Consumption (physiology)
• Reference Values
• Stroke Volume (physiology)
• Thrombolytic Therapy
• Tomography, Emission-Computed