Cardio-respiratory control in an infant with Ondine's curse: a multivariate autoregressive modelling approach.

Abstract

We applied spectral analysis through multivariant autoregressive model fitting [1] to RR interval (RRI) and respiratory (RES) oscillation obtained during quiet sleep in an infant with congenital central hypoventilation syndrome (Ondine's curse), a child with obstructive sleep apnea, and two healthy children. Power spectra, impulse response and noise contribution ratio between RRI and RES oscillation were calculated by using a minicomputer PFU-1200 (FACOM) to determine the structure of the feedback system between RRI and RES within the central nervous system. We found that the respiratory noise contribution ratio to RRI was significantly smaller in Ondine's curse (37 +/- 7.7%, at 0.23 Hz) than in obstructive sleep apnea (90 +/- 6.7%, at 0.39 Hz) and healthy subjects. We postulate that the result shows disturbance of the central autonomic control of breathing and heart rate in Ondine's curse.

• Authors: T Ogawa, M Kojo, N Fukushima, H Sonoda, K Goto, S Ishiwa, M Ishiguro
• Journal: Journal of the autonomic nervous system (J Auton Nerv Syst) Vol. 42 Issue 1 Pg. 41-52 (Jan 1993) ISSN: 0165-1838 [Print] Netherlands
• PMID: 8436805 (Publication Type: Case Reports, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Autonomic Nervous System (physiopathology)
• Child
• Child, Preschool
• Electrocardiography
• Heart Rate
• Humans
• Infant
• Infant, Newborn
• Male
• Models, Neurological
• Models, Statistical
• Respiratory Function Tests
• Sleep Apnea Syndromes (physiopathology)