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The Nottingham study of neurotic disorder. Effect of personality status on response to drug treatment, cognitive therapy and self-help over two years.

Abstract
Repeated assessments of psychopathology, together with personality status, were made over two years on 181 psychiatric out-patients with generalised anxiety disorder (59), panic disorder (66), or dysthymic disorder (56) diagnosed using an interview schedule for DSM-III. Patients were randomly allocated to drug treatment, cognitive and behaviour therapy, or a self-help treatment programme. Although there were no overall differences in compliance rate and efficacy between the three modes of treatment, the psychological treatment methods, particularly self-help, were more effective in patients without personality disorder, and those with personality disorder responded better to drug treatment, primarily antidepressants. The findings suggest that assessment of personality status could be a valuable aid to selection of treatment in neurotic disorders and that self-help approaches are particularly valuable once personality disorder has been excluded.
AuthorsP Tyrer, N Seivewright, B Ferguson, S Murphy, A L Johnson
JournalThe British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 162 Pg. 219-26 (Feb 1993) ISSN: 0007-1250 [Print] England
PMID8435693 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Diazepam
  • Dothiepin
Topics
  • Adult
  • Anxiety Disorders (psychology, therapy)
  • Cognitive Behavioral Therapy
  • Depressive Disorder (psychology, therapy)
  • Diazepam (therapeutic use)
  • Dothiepin (therapeutic use)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neurotic Disorders (psychology, therapy)
  • Panic Disorder (psychology, therapy)
  • Personality Assessment
  • Self-Help Groups

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