Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis.

Abstract

We report the results of a 2-week double-blind, parallel clinical trial comparing two superpotent topical glucocorticosteroid ointments, diflorasone diacetate 0.05% and betamethasone dipropionate 0.05%, in psoriatic adults. Both corticosteroid ointments were fast acting and highly efficacious. 40 of the 44 patients who initially enrolled completed the trial. There were no statistically significant differences between the two glucocorticoids with respect to erythema, scaling, induration or the investigator's global evaluation after either 1 or 2 weeks of therapy. The level of patient satisfaction with the efficacy and cosmetic acceptability of these two category I glucocorticoids was similar. No systemic or local adverse reactions were noted.

• Authors: J L Shupack, L Jondreau, C Kenny, M J Stiller
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 186 Issue 2 Pg. 129-32 ( 1993) ISSN: 1018-8665 [Print] Switzerland
• PMID: 8428041 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anti-Inflammatory Agents
• Glucocorticoids
• Ointments
• betamethasone-17,21-dipropionate
• Betamethasone
• diflorasone

Topics

• Administration, Topical
• Adult
• Aged
• Aged, 80 and over
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Betamethasone (administration & dosage, analogs & derivatives, therapeutic use)
• Double-Blind Method
• Esthetics
• Female
• Glucocorticoids
• Humans
• Male
• Middle Aged
• Ointments
• Patient Satisfaction
• Psoriasis (drug therapy, pathology)