Familial meningioma is not allelic to neurofibromatosis 2.

Abstract

Meningiomas frequently lose parts of chromosome 22 (CHR 22), suggesting that a meningioma tumor-suppressor gene is located on CHR 22. Since meningiomas are common in neurofibromatosis 2 (NF2) and the NF2 gene is mapped to CHR 22, the NF2 gene is a candidate for the meningioma gene. To determine whether NF2 and familial meningioma are allelic mutations, we studied a family with multiple meningiomas and ependymomas in two generations using genetic linkage analysis with DNA markers known to flank the NF2 locus. Multipoint linkage analysis resulted in location scores < -2 for a region of 15 cM including the NF2 region. These results support the existence of a familial meningioma locus that is distinct from the NF2 locus.

• Authors: S M Pulst, G A Rouleau, C Marineau, P Fain, J P Sieb
• Journal: Neurology (Neurology) Vol. 43 Issue 10 Pg. 2096-8 (Oct 1993) ISSN: 0028-3878 [Print] United States
• PMID: 8413972 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA Primers
• DNA Probes
• DNA, Satellite
• Genetic Markers

Topics

• Alleles
• Base Sequence
• Chromosome Aberrations
• Chromosomes, Human, Pair 22
• DNA Primers
• DNA Probes
• DNA, Satellite (genetics)
• Female
• Genetic Linkage
• Genetic Markers
• Humans
• Male
• Meningeal Neoplasms (genetics)
• Meningioma (genetics)
• Molecular Sequence Data
• Neurofibromatosis 2 (genetics)
• Pedigree
• Software