Abstract | OBJECTIVE: DESIGN: Randomized, placebo-controlled, parallel-group, double-blind trial. SETTING: Twelve outpatient clinics across the United States affiliated with programs in either geriatrics, gynecology, or urology. PARTICIPANTS: Ninety-eight women, age 60 or older, with symptoms of urge incontinence and self-reported frequency of incontinence four or more times per week and involuntary bladder contractions on dual- channel water cystometry. MAIN OUTCOME MEASURES: Self-reported urinary frequency, urgency, number of incontinence episodes, and number of heavily soaked pads. RESULTS: Eighty-one women, average age 71, completed the trial, 40 in the active drug group, 41 in the placebo group. Incontinence frequency and the number of heavily soaked pads were reduced in the active drug group by 64% and 55%, respectively, and by 21% (P = 0.002) and 9% (P = 0.04) in the placebo group. No patients dropped out due to adverse effects. An intention-to-treat analysis of all 98 patients yielded the same conclusion. CONCLUSION:
|
Authors | |
Journal | Journal of the American Geriatrics Society
(J Am Geriatr Soc)
Vol. 41
Issue 9
Pg. 915-22
(Sep 1993)
ISSN: 0002-8614 [Print] United States |
PMID | 8409177
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Butylamines
- Parasympatholytics
- terodiline
|
Topics |
- Aged
- Aged, 80 and over
- Ambulatory Care Facilities
- Butylamines
(pharmacology, therapeutic use)
- Diabetes Complications
- Double-Blind Method
- Female
- Humans
- Linear Models
- Middle Aged
- Parasympatholytics
(pharmacology, therapeutic use)
- Time Factors
- Torsades de Pointes
(chemically induced)
- Urinary Incontinence
(complications, diagnosis, drug therapy, epidemiology)
- Urodynamics
|