Management of lentigo maligna and lentigo maligna melanoma with paraffin-embedded tangential sections: utility of immunoperoxidase staining and supplemental vertical sections.

Abstract

BACKGROUND:

The use of frozen sections in the management of lentigo maligna and lentigo maligna melanoma has been the focus of some controversy.

OBJECTIVE:

Our purpose was to utilize paraffin-embedded tangential sections in the management of two cases of lentigo maligna and three cases of lentigo maligna melanoma.

METHODS:

A modification of Mohs micrographic surgery using rush paraffin-embedded sections with adjunctive immunoperoxidase staining (HMB-45) and supplemental vertical sections was employed.

RESULTS:

This method resulted in enhanced histologic evaluation of section margins and did not compromise the diagnosis of the primary invasive melanoma or Breslow measurements.

CONCLUSION:

Mohs micrographic surgery modified by the use of rush paraffin-embedded sections allows adjunctive immunoperoxidase staining and supplemental vertical sections that may be helpful in the management of lentigo maligna and lentigo maligna melanoma.

• Authors: M R Stonecipher, B Leshin, J Patrick, W L White
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 29 Issue 4 Pg. 589-94 (Oct 1993) ISSN: 0190-9622 [Print] United States
• PMID: 8408795 (Publication Type: Case Reports, Journal Article)

Topics

• Aged
• Face
• Frozen Sections
• Humans
• Hutchinson's Melanotic Freckle (pathology, surgery)
• Immunoenzyme Techniques
• Male
• Melanoma (pathology, surgery)
• Middle Aged
• Mohs Surgery (methods)
• Paraffin Embedding
• Skin Neoplasms (pathology, surgery)