Abstract |
Escherichia coli H.I.8, an O128 infant diarrhea isolate, produces low titers of a unique Shiga-like toxin (SLT), called SLT-IIva, which is a variant of SLT-II. We investigated induction of toxin synthesis and the putative association of a bacteriophage with toxin synthesis. Induction of broth cultures of strain H.I.8 with mitomycin yielded a 3,000-fold increase in SLT-IIva, production of a colicin, and appearance of a bacteriophage. Southern hybridization demonstrated that the genes for SLT-IIva were not carried by the bacteriophage.
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Authors | A J Yee, S De Grandis, C L Gyles |
Journal | Infection and immunity
(Infect Immun)
Vol. 61
Issue 10
Pg. 4510-3
(Oct 1993)
ISSN: 0019-9567 [Print] United States |
PMID | 8406845
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bacterial Toxins
- Oligodeoxyribonucleotides
- Shiga Toxin 1
- Shiga Toxin 2
- Mitomycin
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Topics |
- Bacterial Toxins
(biosynthesis)
- Base Sequence
- Chromosomes, Bacterial
(ultrastructure)
- Escherichia coli
(genetics, pathogenicity)
- Gene Expression Regulation, Bacterial
(drug effects)
- Genes, Bacterial
- Mitomycin
(pharmacology)
- Molecular Sequence Data
- Oligodeoxyribonucleotides
(chemistry)
- Shiga Toxin 1
- Shiga Toxin 2
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