Absence of hepatic uptake of Tc-99m phytate in a man with chronic toluene hepatotoxicity.

Abstract

The case reported here is of a 28-year-old man diagnosed as having toluene hepatotoxicity. He had a 5-year history of exposure to toluene and was admitted to hospital complaining of two episodes of loss of consciousness. The high total bilirubin and the low prothrombin time suggested serious liver dysfunction. Based on histologic examination of a liver biopsy specimen, the diagnosis of toxic liver dysfunction caused by toluene poisoning was made. Hepatic images were not present in Tc-99m phytate scintigrams, but they were present in hepatobiliary scintigrams done with the Tc-99m N-pyridoxyl-5-methyltryptophan. The diagnosis of hepatic reticuloendothelial failure was made.

• Authors: S Shiomi, T Kuroki, T Kuroda, T Ueda, S Nishiguchi, K Kobayashi, H Ochi
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 18 Issue 8 Pg. 655-6 (Aug 1993) ISSN: 0363-9762 [Print] United States
• PMID: 8403694 (Publication Type: Case Reports, Journal Article)

Chemical References

• Organotechnetium Compounds
• technetium phytate
• Toluene
• Phytic Acid

Topics

• Adult
• Chronic Disease
• Humans
• Liver Failure (chemically induced, diagnostic imaging)
• Male
• Mononuclear Phagocyte System (diagnostic imaging, drug effects)
• Occupational Diseases (chemically induced, diagnostic imaging)
• Organotechnetium Compounds
• Phytic Acid
• Radionuclide Imaging
• Toluene (poisoning)