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Cytoplasmic GpIIb-IIIa and cytokine secretion by blasts in a case of megakaryoblastic transformation of essential thrombocythemia.

Abstract
A 49-year-old woman with a four year history of therapy resistant essential thrombocythemia, progressed to acute leukemia that also proved refractory to chemotherapy. Blast cell features including immunophenotype, cytogenetics and in vitro cell cultures, suggested megakaryoblastic leukemia. In serum-free culture, blasts released GM-CSF and IL-6 which sustained autocrine growth and promoted normal myeloid and megakaryocytic colony formation.
AuthorsC Selleri, F Alfinito, L Del Vecchio, L Luciano, A De Renzo, B Rotoli
JournalLeukemia & lymphoma (Leuk Lymphoma) Vol. 10 Issue 6 Pg. 497-500 (Aug 1993) ISSN: 1042-8194 [Print] United States
PMID8401187 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antigens, CD
  • Antigens, Neoplasm
  • Cytokines
  • Platelet Membrane Glycoproteins
Topics
  • Antigens, CD (analysis)
  • Antigens, Neoplasm (analysis)
  • Cytokines (immunology)
  • Female
  • Humans
  • Immunophenotyping
  • Leukemia, Megakaryoblastic, Acute (etiology, immunology, pathology)
  • Lymphocyte Activation (immunology, physiology)
  • Middle Aged
  • Platelet Membrane Glycoproteins (immunology)
  • Thrombocythemia, Essential (immunology, pathology, physiopathology)

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