Abstract |
A 49-year-old woman with a four year history of therapy resistant essential thrombocythemia, progressed to acute leukemia that also proved refractory to chemotherapy. Blast cell features including immunophenotype, cytogenetics and in vitro cell cultures, suggested megakaryoblastic leukemia. In serum-free culture, blasts released GM-CSF and IL-6 which sustained autocrine growth and promoted normal myeloid and megakaryocytic colony formation.
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Authors | C Selleri, F Alfinito, L Del Vecchio, L Luciano, A De Renzo, B Rotoli |
Journal | Leukemia & lymphoma
(Leuk Lymphoma)
Vol. 10
Issue 6
Pg. 497-500
(Aug 1993)
ISSN: 1042-8194 [Print] United States |
PMID | 8401187
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antigens, CD
- Antigens, Neoplasm
- Cytokines
- Platelet Membrane Glycoproteins
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Topics |
- Antigens, CD
(analysis)
- Antigens, Neoplasm
(analysis)
- Cytokines
(immunology)
- Female
- Humans
- Immunophenotyping
- Leukemia, Megakaryoblastic, Acute
(etiology, immunology, pathology)
- Lymphocyte Activation
(immunology, physiology)
- Middle Aged
- Platelet Membrane Glycoproteins
(immunology)
- Thrombocythemia, Essential
(immunology, pathology, physiopathology)
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