Prophylactic effect of milbemycin oxime against Dirofilaria immitis infection in dogs: optimum dose and administration time.

Abstract

To examine the prophylactic efficacy of milbemycin oxime against Dirofilaria immitis infection, 42 filaria-free beagles were inoculated with 100 infective larvae of the parasite. Milbemycin oxime was administered orally at doses of 0.05 to 1.0 mg/kg body weight one month after inoculation, and at a single dose of 0.25 mg/kg body weight on days 1 to 90 after inoculation. All dogs were euthanized and autopsied to evaluate the prophylactic effect of the drug against D. immitis infection 6 months after inoculation. It was confirmed that a dose of 0.25 mg/kg of milbemycin oxime completely-protected the infection 15 to 60 days after infection.

• Authors: M Tagawa, S Okano, Y Hayashi, K Kusano
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 55 Issue 4 Pg. 693-4 (Aug 1993) ISSN: 0916-7250 [Print] Japan
• PMID: 8399759 (Publication Type: Journal Article)

Chemical References

• Anthelmintics
• Anti-Bacterial Agents
• Macrolides
• milbemycin oxime

Topics

• Animals
• Anthelmintics (therapeutic use)
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Dirofilaria immitis (isolation & purification)
• Dirofilariasis (prevention & control)
• Dog Diseases (prevention & control)
• Dogs
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Female
• Larva
• Macrolides
• Male