Prophylactic effect of milbemycin oxime against Dirofilaria immitis infection in dogs: optimum dose and administration time.

To examine the prophylactic efficacy of milbemycin oxime against Dirofilaria immitis infection, 42 filaria-free beagles were inoculated with 100 infective larvae of the parasite. Milbemycin oxime was administered orally at doses of 0.05 to 1.0 mg/kg body weight one month after inoculation, and at a single dose of 0.25 mg/kg body weight on days 1 to 90 after inoculation. All dogs were euthanized and autopsied to evaluate the prophylactic effect of the drug against D. immitis infection 6 months after inoculation. It was confirmed that a dose of 0.25 mg/kg of milbemycin oxime completely-protected the infection 15 to 60 days after infection.
AuthorsM Tagawa, S Okano, Y Hayashi, K Kusano
JournalThe Journal of veterinary medical science / the Japanese Society of Veterinary Science (J Vet Med Sci) Vol. 55 Issue 4 Pg. 693-4 (Aug 1993) ISSN: 0916-7250 [Print] JAPAN
PMID8399759 (Publication Type: Journal Article)
Chemical References
  • Anthelmintics
  • Anti-Bacterial Agents
  • Macrolides
  • milbemycin oxime
  • Animals
  • Anthelmintics (therapeutic use)
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Dirofilaria immitis (isolation & purification)
  • Dirofilariasis (prevention & control)
  • Dog Diseases (prevention & control)
  • Dogs
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Larva
  • Macrolides
  • Male

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: