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Prophylactic effect of milbemycin oxime against Dirofilaria immitis infection in dogs: optimum dose and administration time.

Abstract
To examine the prophylactic efficacy of milbemycin oxime against Dirofilaria immitis infection, 42 filaria-free beagles were inoculated with 100 infective larvae of the parasite. Milbemycin oxime was administered orally at doses of 0.05 to 1.0 mg/kg body weight one month after inoculation, and at a single dose of 0.25 mg/kg body weight on days 1 to 90 after inoculation. All dogs were euthanized and autopsied to evaluate the prophylactic effect of the drug against D. immitis infection 6 months after inoculation. It was confirmed that a dose of 0.25 mg/kg of milbemycin oxime completely-protected the infection 15 to 60 days after infection.
AuthorsM Tagawa, S Okano, Y Hayashi, K Kusano
JournalThe Journal of veterinary medical science / the Japanese Society of Veterinary Science (J Vet Med Sci) Vol. 55 Issue 4 Pg. 693-4 (Aug 1993) ISSN: 0916-7250 [Print] JAPAN
PMID8399759 (Publication Type: Journal Article)
Chemical References
  • Anthelmintics
  • Anti-Bacterial Agents
  • Macrolides
  • milbemycin oxime
Topics
  • Animals
  • Anthelmintics (therapeutic use)
  • Anti-Bacterial Agents (administration & dosage, therapeutic use)
  • Dirofilaria immitis (isolation & purification)
  • Dirofilariasis (prevention & control)
  • Dog Diseases (prevention & control)
  • Dogs
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Larva
  • Macrolides
  • Male

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