Effects of haloperidol on a run-climb-run behavioral task: distance climbed does not alter within-session decrements.

Abstract

Effects of haloperidol (0.04-0.32 mg/kg) were assessed in 10 hungry rats trained in a 10-trials-per-day format to run down an alleyway, climb a vertical rope, and run across a horizontal board to obtain sweetened milk. Rope lengths of 0.59 m and 1.32 m defined low- and high-effort requirements, respectively. Haloperidol produced substantial within-session decrements on Trials 2-10, but the drug did not affect rope-climbing speed more than horizontal running speed. Drug-induced within-session decrements were similar for both low- and high-effort requirements. After treatment with the 0.16-mg/kg dose, force-time waveforms of the climbing behavior documented instances of arrest of movement on the rope, but no bradykinesia of individual locomotor acts was discerned. Results suggest that haloperidol may produce associative deficits as well as disruptions of motor processes.

• Authors: S C Fowler, L Senyuz
• Journal: Behavioral neuroscience (Behav Neurosci) Vol. 107 Issue 4 Pg. 651-61 (Aug 1993) ISSN: 0735-7044 [Print] United States
• PMID: 8397869 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Haloperidol

Topics

• Animals
• Appetitive Behavior (drug effects)
• Dose-Response Relationship, Drug
• Haloperidol (pharmacology)
• Male
• Motivation
• Motor Activity (drug effects)
• Motor Skills (drug effects)
• Orientation (drug effects)
• Rats
• Rats, Sprague-Dawley
• Reaction Time (drug effects)