Abstract |
Azithromycin has activity in vitro against Chlamydia trachomatis, and its novel pharmacokinetics suggest that even single doses may be effective in the treatment of non-gonococcal urethritis (NGU). This study compared the efficacy and safety of a single 1 g oral dose of azithromycin versus doxycycline 100 mg bid for seven days in the treatment of NGU. Men with symptoms and/or signs of NGU, and with > or = 5 polymorphonuclear leucocytes/high-power field in a Gram's-stained urethral smear, were recruited. Investigations included endourethral swabs for C. trachomatis cell culture. Patients were randomized to receive azithromycin or doxycycline, and were re-assessed on day 7-10 and on day 14-21. Of the 143 men recruited, C. trachomatis was isolated from 51 (40%) of the 128 evaluable patients. Both treatments were well tolerated and had comparable cure rates. Azithromycin 1 g appears to be an effective and safe alternative to doxycycline for the treatment of chlamydial and non-chlamydial urethritis, and its single-dose administration is an advantage in terms of patient compliance.
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Authors | P J Lister, T Balechandran, G L Ridgway, A J Robinson |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 31 Suppl E
Pg. 185-92
(Jun 1993)
ISSN: 0305-7453 [Print] England |
PMID | 8396092
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Erythromycin
- Azithromycin
- Doxycycline
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Topics |
- Administration, Oral
- Adult
- Azithromycin
- Chlamydia Infections
(drug therapy)
- Chlamydia trachomatis
- Doxycycline
(adverse effects, therapeutic use)
- Drug Administration Schedule
- Erythromycin
(adverse effects, analogs & derivatives, therapeutic use)
- Humans
- Male
- Middle Aged
- Neisseria gonorrhoeae
- Neisseriaceae Infections
- Urethritis
(drug therapy, microbiology)
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