Abstract |
This study evaluated the antinociceptive effects of systemically administered selective opioid agonists of mu ( DAMGO), delta ( BUBU) and kappa ( U 69593) receptors on the vocalization threshold to paw pressure in a rat model of peripheral unilateral mononeuropathy produced by loose ligatures around the common sciatic nerve. DAMGO (0.5-2 mg/kg), BUBU (1.5-6 mg/kg) and U 69593 (0.75-3 mg/kg) injected intravenously (i.v.) produced a potent long-lasting antinociceptive effect on both hind paws. The effects on the lesioned paw were clearly and statistically more potent than for the non-lesioned paw. The selective antinociceptive effect of 2 mg/kg DAMGO, 3 mg/kg BUBU and 1.5 mg/kg U 69593 were completely prevented by prior administration of the appropriate antagonists: 0.1 mg/kg naloxone, 1 mg/kg naltrindole and 0.4 mg/kg MR 2266. The present data clearly show that an acute i.v. injection of these selective opioid agonists induces potent antinociceptive effects in a rat model of peripheral neuropathy. These data are discussed with regard to the classical view that there is opioid resistance in neuropathic pain.
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Authors | J A Desmeules, V Kayser, G Guilbaud |
Journal | Pain
(Pain)
Vol. 53
Issue 3
Pg. 277-285
(Jun 1993)
ISSN: 0304-3959 [Print] United States |
PMID | 8394563
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Benzeneacetamides
- Benzomorphans
- Enkephalins
- Narcotic Antagonists
- Oligopeptides
- Pyrrolidines
- Receptors, Opioid
- Receptors, Opioid, delta
- Receptors, Opioid, kappa
- Receptors, Opioid, mu
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- tyrosyl-seryl(O-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(O-t-butyl)
- Naloxone
- MR 2266
- Naltrexone
- naltrindole
- U 69593
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Topics |
- Analgesics
(therapeutic use)
- Animals
- Benzeneacetamides
- Benzomorphans
(pharmacology)
- Disease Models, Animal
- Drug Interactions
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- Enkephalins
(therapeutic use)
- Male
- Naloxone
(pharmacology)
- Naltrexone
(analogs & derivatives, pharmacology)
- Narcotic Antagonists
(pharmacology)
- Oligopeptides
(therapeutic use)
- Pain
(drug therapy)
- Pain Measurement
(drug effects)
- Pain Threshold
(drug effects)
- Pyrrolidines
(therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Receptors, Opioid
(drug effects)
- Receptors, Opioid, delta
(drug effects)
- Receptors, Opioid, kappa
(drug effects)
- Receptors, Opioid, mu
(drug effects)
- Vocalization, Animal
(drug effects)
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