Abstract |
The relationship between alpha 1-antitrypsin deficiency (alpha 1-ATD) and the HLA antigen system was studied in 32 liver transplant recipients. Despite previous reports of an association of HLA antigen DR3 with homozygosity for alpha 1-AT ZZ, no such association was seen in this population of alpha 1-ATD homozygous ZZ patients with advanced hepatic disease. Thus, the reported association of HLA class II antigens and homozygosity for the Z allele for alpha 1-AT may be an artifact of either a small study population or geographic inbreeding and a coincidental association of certain HLA antigens with the presence of homozygosity for the Z allele of alpha 1-AT.
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Authors | A Casavilla, R Gordon, D H van Thiel, T E Starzl |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 38
Issue 8
Pg. 1489-91
(Aug 1993)
ISSN: 0163-2116 [Print] United States |
PMID | 8393758
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Carcinoma, Hepatocellular
(complications, pathology)
- Child
- Child, Preschool
- Female
- HLA-DR3 Antigen
(analysis)
- Humans
- Infant
- Liver Neoplasms
(complications, pathology)
- Liver Transplantation
(immunology)
- Male
- Middle Aged
- Phenotype
- Reference Values
- alpha 1-Antitrypsin Deficiency
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