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Lack of association between HLA antigen DR3 and alpha 1-antitrypsin deficiency in liver transplant recipients.

Abstract
The relationship between alpha 1-antitrypsin deficiency (alpha 1-ATD) and the HLA antigen system was studied in 32 liver transplant recipients. Despite previous reports of an association of HLA antigen DR3 with homozygosity for alpha 1-AT ZZ, no such association was seen in this population of alpha 1-ATD homozygous ZZ patients with advanced hepatic disease. Thus, the reported association of HLA class II antigens and homozygosity for the Z allele for alpha 1-AT may be an artifact of either a small study population or geographic inbreeding and a coincidental association of certain HLA antigens with the presence of homozygosity for the Z allele of alpha 1-AT.
AuthorsA Casavilla, R Gordon, D H van Thiel, T E Starzl
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 38 Issue 8 Pg. 1489-91 (Aug 1993) ISSN: 0163-2116 [Print] United States
PMID8393758 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • HLA-DR3 Antigen
Topics
  • Adolescent
  • Adult
  • Carcinoma, Hepatocellular (complications, pathology)
  • Child
  • Child, Preschool
  • Female
  • HLA-DR3 Antigen (analysis)
  • Humans
  • Infant
  • Liver Neoplasms (complications, pathology)
  • Liver Transplantation (immunology)
  • Male
  • Middle Aged
  • Phenotype
  • Reference Values
  • alpha 1-Antitrypsin Deficiency

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