[A combination chemotherapy of carboplatin and etoposide for malignant fibrous histiocytoma with marked effect on the metastatic lung region].

Abstract

For metastatic lung region, a 82-year-old woman with malignant fibrous histiocytoma was successfully treated with combination chemotherapy of Carboplatin and Etoposide. First, the tumor appeared on her right thigh, and we operated on August 1991. However, at the same time, a metastatic lung region was also noticed. Over a year, it worsened. We gave her 350 mg Carboplatin once a week and 100 mg Etoposide 3 times a week. After 3 weeks' treatment, we stopped treatment because of sudden granulocytopenia and thrombocytopenia. But to our surprise, the metastatic lung region almost disappeared 2 months after therapy. Considering the difficulty of medical treatment for malignant fibrous histiocytoma, this case suggests that combination chemotherapy of Carboplatin and Etoposide is valuable. However, due care must be taken for side effects such as granulocytopenia and thrombocytopenia.

• Authors: K Yasuno, W Matsunaga, T Ishihara
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 20 Issue 9 Pg. 1253-6 (Jul 1993) ISSN: 0385-0684 [Print] Japan
• PMID: 8392828 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Etoposide
• Carboplatin

Topics

• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carboplatin (administration & dosage)
• Drug Administration Schedule
• Etoposide (administration & dosage)
• Female
• Histiocytoma, Benign Fibrous (drug therapy, secondary)
• Humans
• Lung Neoplasms (drug therapy, secondary)
• Soft Tissue Neoplasms (pathology)