Efficacy of (-)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in African green monkeys infected with simian varicella virus.

(-)-9-[4-Hydroxy-2-(hydroxymethyl)butyl]guanine was evaluated for its efficacy in African green monkeys infected with simian varicella virus. Treatment by intramuscular injection was initiated 48 h after virus inoculation and was continued for 10 days; the treatment showed therapeutic effects on rash and viremia at dosages down to 1 mg/kg of body weight per day.
AuthorsK F Soike, R Bohm, J L Huang, B Oberg
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 37 Issue 6 Pg. 1370-2 (Jun 1993) ISSN: 0066-4804 [Print] UNITED STATES
PMID8392312 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antiviral Agents
  • penciclovir
  • Acyclovir
  • Acyclovir (analogs & derivatives, pharmacology)
  • Animals
  • Antiviral Agents (pharmacology)
  • Cercopithecus aethiops
  • Dose-Response Relationship, Drug
  • Herpesviridae
  • Herpesviridae Infections (blood, drug therapy)

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