Human papillomavirus, human cytomegalovirus and oncogene C-myc in cervical carcinoma and cervicitis.

Abstract

HPV-16 and HCMV DNA homologous sequence and the status of cellular oncogene C-myc DNA were examined in uterine cervical diseases with dot blot hybridization and Southern hybridization. The results showed a positive rate of 70.8% in HPV-16 and 38.7% in HCMV in cervical carcinoma, and that of 36.7% in HPV-16 and 16.7% in HCMV in cervicitis. C-myc DNA was widely detectable in uterine cervical carcinoma, but the manifestation of translocation, deletion or overexpression in cervical carcinoma was frequent. The value of these findings in the development of cervical carcinoma is discussed.

• Authors: S L Huang, Z Q Liu, X N Zhang, M J Li
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 106 Issue 3 Pg. 208-10 (Mar 1993) ISSN: 0366-6999 [Print] China
• PMID: 8391967 (Publication Type: Journal Article)

Chemical References

• DNA, Viral

Topics

• Blotting, Southern
• Cytomegalovirus (isolation & purification)
• DNA, Viral (analysis)
• Female
• Gene Expression Regulation, Viral
• Genes, myc
• Humans
• Papillomaviridae (isolation & purification)
• Translocation, Genetic
• Uterine Cervical Neoplasms (genetics, microbiology)
• Uterine Cervicitis (genetics, microbiology)