[The myocardial protective effects of cardiac tissue ACE inhibition in experimental ischemia-reperfusion in isolated rat hearts].

Abstract

The protective effects of captopril were evaluated in vitro on isolated perfused rat hearts after a global ischemia of 20 min. The hearts were randomly allocated in 2 groups. In the first one (n = 6) captopril was added at a concentration of 270 microM. The second one was utilized as control (n = 6). Aortic flow and minute work respectively decreased on reperfusion by 35% and 49% in captopril group and by 65% and 71% in controls (p < 0.001). No changes occurred in heart rate. Aortic systolic pressure and coronary flow decreased in the 2 groups, but not significantly. Myocardial enzyme release during reperfusion showed significant lower levels of CPK and LDH in the captopril group as compared to controls (p < 0.001 after 41 min). The occurrence of serious ventricular arrhythmias was considerably higher in controls with respect to the captopril group. Irreversible ventricular fibrillation occurred only in control hearts (50%). These data indicate that captopril exerts a protective effect during myocardial ischemia and reperfusion by preventing serious ventricular arrhythmias, reducing enzymatic release and a lower decrease in cardiac performance, without an increase in heart rate.

• Authors: P Di Napoli, G Di Gregorio, F De Sanctis, S Gallina, E Di Girolamo, G P Trevi, A Barsotti
• Journal: Cardiologia (Rome, Italy) (Cardiologia) Vol. 38 Issue 2 Pg. 107-12 (Feb 1993) ISSN: 0393-1978 [Print] Italy
• Vernacular Title: Effetti miocardioprotettivi dell'ACE-inibizione tessutale cardiaca nell'ischemia-riperfusione sperimentale in cuori isolati di ratto.
• PMID: 8391928 (Publication Type: Comparative Study, English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Captopril
• L-Lactate Dehydrogenase
• Creatine Kinase
• Peptidyl-Dipeptidase A

Topics

• Animals
• Captopril (therapeutic use)
• Creatine Kinase (drug effects, metabolism)
• Drug Evaluation, Preclinical
• Heart (drug effects)
• Hemodynamics (drug effects)
• In Vitro Techniques
• L-Lactate Dehydrogenase (drug effects, metabolism)
• Male
• Myocardial Reperfusion Injury (enzymology, physiopathology, prevention & control)
• Myocardium (enzymology)
• Peptidyl-Dipeptidase A (drug effects, metabolism)
• Random Allocation
• Rats