[Efficacy of xiaoxingzhang guttae ophthalmic eye drops in the treatment of experimental herpes simplex keratitis].

Abstract

The new guttae ophthalmic Xiaoxingzhang (XXZ) was extracted from Radix Actinidiae, a traditional Chinese herbal drug. The 50% inhibition concentration (IC50) of XXZ on type I Herpes Simplex Virus (HSV-1) in virus cell cultures is 165.48-174.73 micrograms/ml. However, XXZ concentrations greater than 400 micrograms/ml did not cause any microscopically visible disruption of vero cells. The efficacy of XXZ in the treatment of experimental Herpes Simplex Keratitis (HSK) in rabbits is higher than that of idoxuridine. The effective doses of XXZ are not toxic to corneal epithelium. The results suggest that XXZ as a new anti-HSV preparation is potentialy useful in the treatment of patients with HSK.

• Authors: J M Zhang, P F Lin, L L Chen, L H Tang, X Q Hong, B X Liang, H S Chen, L Teng
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 18 Issue 1 Pg. 49-52, 64 (Jan 1993) ISSN: 1001-5302 [Print] China
• PMID: 8391822 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Drugs, Chinese Herbal
• Ophthalmic Solutions
• Polysaccharides

Topics

• Adjuvants, Immunologic (pharmacology, therapeutic use)
• Animals
• Cornea (pathology)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Fruit
• Keratitis, Herpetic (drug therapy, pathology)
• Male
• Ophthalmic Solutions
• Polysaccharides (pharmacology, therapeutic use)
• Rabbits
• Simplexvirus (drug effects, growth & development)
• Viral Plaque Assay