Hairy leukoplakia after bone marrow transplantation.

Abstract

Hairy leukoplakia in 10 patients after bone marrow transplantation was identified clinically and assessed histologically. In situ hybridization for Epstein-Barr virus and human papilloma virus confirmed Epstein-Barr virus in hairy leukoplakia in two cases, and human papillomavirus in three cases. All cases with clinical follow-up resolved without treatment. These findings suggest that severe immunosuppression after a bone marrow transplantation may result in the development of hairy leukoplakia, and that as the immunosuppression resolves after the transplant the lesions also resolve.

• Authors: J B Epstein, C H Sherlock, R A Wolber
• Journal: Oral surgery, oral medicine, and oral pathology (Oral Surg Oral Med Oral Pathol) Vol. 75 Issue 6 Pg. 690-5 (Jun 1993) ISSN: 0030-4220 [Print] United States
• PMID: 8390632 (Publication Type: Journal Article)

Chemical References

• DNA, Viral

Topics

• Adolescent
• Adult
• Bone Marrow Transplantation (adverse effects)
• DNA, Viral (analysis)
• Female
• Herpesvirus 4, Human (genetics)
• Humans
• Immunosuppression Therapy (adverse effects)
• In Situ Hybridization
• Leukoplakia, Oral (etiology, microbiology)
• Male
• Middle Aged
• Mouth Neoplasms (etiology, microbiology)
• Papillomaviridae (genetics)