Lineage promiscuity in leukemia studies of T-cell receptor and immunoglobulin genes.

Abstract

Using appropriate DNA probes, the configurations of the T-cell receptor beta-chain genes and immunoglobulin heavy-chain genes were studied in patients diagnosed as having the following malignancies: 7 chronic myeloid leukemia, 13 acute myeloblastic leukemia, 9 acute lymphocytic leukemia and 20 chronic lymphocytic leukemia. Rearrangements not corresponding to the immunotype were unexpectedly found in lineage neoplasias.

• Authors: D Bernard, Y J Bignon, F Lavenue, J Pauchard, F Demeocq, P Travade, P Philippe, M Legros, H Cure, J Chassagne
• Journal: Leukemia research (Leuk Res) Vol. 17 Issue 5 Pg. 445-53 (May 1993) ISSN: 0145-2126 [Print] England
• PMID: 8388969 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Burkitt Lymphoma (blood, genetics)
• Gene Rearrangement
• Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
• Genes, Immunoglobulin
• Genotype
• Humans
• Immunophenotyping
• Leukemia (blood, genetics)
• Leukemia, Lymphocytic, Chronic, B-Cell (blood, genetics)
• Leukemia, Prolymphocytic, T-Cell (blood, genetics)
• Leukemia-Lymphoma, Adult T-Cell (blood, genetics)