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Hypotonic cisplatin treatment for carcinomatous pleuritis found at thoracotomy in patients with lung cancer. In vitro experiments and preliminary clinical results.

Abstract
We have developed an intraoperative intrapleural treatment with the use of distilled water combined with cisplatin for carcinomatous pleuritis found at thoracotomy in patients with non-small-cell lung cancer. In the in vitro experiment, three different cell lines were used as a model of malignant pleural effusion. Cell growth was examined after a 3-day culture, which was preceded by exposure of the cells to cisplatin in either phosphate-buffered saline solution or distilled water for 1/2 to 5 minutes. The growth inhibition of tumor cells after hypotonic cisplatin treatment was significantly greater than after treatment with saline solution and cisplatin. Tumor that was obtained by resection of non-small-cell lung cancer was used as a model to demonstrate decreased viability of the tumor after exposure to hypotonic cisplatin. The viability of the tumor in a 6-day culture, preceded by exposure to hypotonic cisplatin (50 micrograms/ml) for 10 minutes, was markedly decreased. Intraoperative intrapleural hypotonic cisplatin was instilled in seven patients with pleural carcinomatosis without side effects and with control of pleural dissemination and pleural effusion for 6 to 29 months.
AuthorsY Ichinose, N Hara, M Ohta, H Asoh, T Yano, K Maeda, K Yagawa
JournalThe Journal of thoracic and cardiovascular surgery (J Thorac Cardiovasc Surg) Vol. 105 Issue 6 Pg. 1041-6 (Jun 1993) ISSN: 0022-5223 [Print] United States
PMID8388966 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Hypotonic Solutions
  • Cisplatin
Topics
  • Aged
  • Carcinoma, Non-Small-Cell Lung (pathology, surgery)
  • Cell Division (drug effects)
  • Cisplatin (therapeutic use)
  • Combined Modality Therapy
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Hypotonic Solutions
  • Intraoperative Care
  • Lung Neoplasms (pathology, surgery)
  • Male
  • Middle Aged
  • Pleural Effusion, Malignant (drug therapy, radiotherapy)
  • Pleural Neoplasms (drug therapy, radiotherapy, secondary)
  • Thoracotomy
  • Treatment Outcome
  • Tumor Cells, Cultured

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