Paniceins and related sesquiterpenoids from the Mediterranean sponge Reniera fulva.

Abstract

Two novel sesquiterpenes, fulvanin 1 [1] and fulvanin 2 [2], have been isolated from the Mediterranean sponge Reniera fulva. Compound 2 is a sesquiterpenoid linked to a hydroquinone. Also found in Reniera fulva are four known paniceins, a group of aromatic sesquiterpenoids linked to a quinol, isolated previously from Halichondria panicea. The total assignments of 13C-nmr spectra of paniceins have been made with the aid of 2D1H-13C correlation techniques, confirming their structures. The paniceins were tested in the in vitro disease-oriented primary antitumor screen at NCI, Bethesda. Paniceins C and B3 showed cytotoxicity against NCI-H522 non-small lung cancer cells and CCRF-CEM leukemia cells, while panicein A hydroquinone revealed more selective cytotoxicity against the latter ones.

• Authors: A Casapullo, L Minale, F Zollo
• Journal: Journal of natural products (J Nat Prod) Vol. 56 Issue 4 Pg. 527-33 (Apr 1993) ISSN: 0163-3864 [Print] United States
• PMID: 8388433 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Sesquiterpenes

Topics

• Animals
• Antineoplastic Agents (isolation & purification, pharmacology)
• Carcinoma, Non-Small-Cell Lung (drug therapy)
• Cell Survival (drug effects)
• Humans
• Lung Neoplasms (drug therapy)
• Magnetic Resonance Spectroscopy
• Porifera (chemistry)
• Sesquiterpenes (isolation & purification, pharmacology)
• Tumor Cells, Cultured