In vitro antiviral activity of polyoxomolybdates. Mechanism of inhibitory effect of PM-104 (NH4)12H2(Eu4(MoO4)(H2O)16(Mo7O24)4).13H2O on human immunodeficiency virus type 1.

Abstract

A screening for inhibitors of human immunodeficiency virus type 1 (HIV-1) among various types of isopolyoxomolybdates and heteropolyoxomolybdates was carried out by using an in vitro assay system measuring the cytopathogenicity of HIV-1 in CD4+ human MT-4 cells. A novel heteropolyoxomolybdate named PM-104 with the chemical formula (NH4)12H2(Eu4(MoO4)(H2O)16(Mo7O24)4).13H2O was found to be associated with potent anti-HIV-1 activity. PM-104 interferes with virus infection at a very early step such as adsorption and/or penetration into the cells. In addition to the cytopathic effect of HIV-1 on MT-4 cells, syncytium formation between mock-infected MOLT-4 cells and MOLT-4 cells chronically infected with either HIV-1 or HIV-2 is suppressed by PM-104. PM-104 also blocks the replication of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The antiviral properties of PM-104 could be attributed to the combined effect of europium atoms and its peculiar three-dimensional anion structure.

• Authors: Y Inouye, Y Tokutake, T Yoshida, Y Seto, H Hujita, K Dan, A Yamamoto, S Nishiya, T Yamase, S Nakamura
• Journal: Antiviral research (Antiviral Res) Vol. 20 Issue 4 Pg. 317-31 (Apr 1993) ISSN: 0166-3542 [Print] Netherlands
• PMID: 8387260 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Organometallic Compounds
• PM 104
• Molybdenum

Topics

• Antiviral Agents (pharmacology)
• Cell Line
• Cytopathogenic Effect, Viral (drug effects)
• HIV-1 (drug effects, physiology)
• Humans
• Microbial Sensitivity Tests
• Molybdenum (pharmacology)
• Organometallic Compounds (pharmacology)
• Simplexvirus (drug effects)
• Virus Replication (drug effects)