Abstract | OBJECTIVES: DESIGN: Prospective, double-blind, randomized trial. SETTING: Veterans Affairs Medical Center (a teaching hospital of the University of California, San Francisco). PATIENTS: INTERVENTIONS: MEASUREMENTS AND MAIN RESULTS:
Bicarbonate treatment significantly increased the mean arterial pH from 7.36 to 7.39; the mean serum bicarbonate concentration from 21 to 25 mmol/L; and PCO2 from 41 to 44 torr (5.5 to 5.9 kPa). Total body oxygen consumption and lactate production did not change. Similarly, no adverse changes occurred in systemic or pulmonary arterial pressures or in cardiac ejection fraction. After bicarbonate administration, both the cardiac output and systemic oxygen consumption decreased by 8% to 11%, while both variables increased by 13% after sodium chloride administration; but, none of the changes was significant. One patient in the bicarbonate group developed myocardial ischemia, compared with three patients in the saline group. CONCLUSIONS:
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Authors | N H Mark, J M Leung, A I Arieff, D T Mangano |
Journal | Critical care medicine
(Crit Care Med)
Vol. 21
Issue 5
Pg. 659-65
(May 1993)
ISSN: 0090-3493 [Print] United States |
PMID | 8386997
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Bicarbonates
- Blood Glucose
- Electrolytes
- Lactates
- Lactic Acid
- Sodium Bicarbonate
- Sodium
- Calcium
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Topics |
- Acidosis, Lactic
(blood, complications, drug therapy)
- Aged
- Bicarbonates
(administration & dosage, pharmacology, therapeutic use)
- Blood Gas Analysis
- Blood Glucose
(drug effects)
- Calcium
(blood)
- Cardiac Output
(drug effects)
- Coronary Disease
(complications)
- Double-Blind Method
- Drug Monitoring
- Electrolytes
- Humans
- Injections, Intravenous
- Intraoperative Complications
(blood, drug therapy)
- Lactates
(blood)
- Lactic Acid
- Male
- Middle Aged
- Monitoring, Intraoperative
- Myocardial Ischemia
(etiology)
- Oxygen Consumption
(drug effects)
- Prospective Studies
- Sodium
(administration & dosage, pharmacology, therapeutic use)
- Sodium Bicarbonate
- Stroke Volume
(drug effects)
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