Abstract |
In view of the well established clinical results of the deprivation of androgens through orchiectomy in prostatic cancer and the structural similarities of 4-androsten-3,17-dione and atamestane (1-methyl-ADD), we studied the influence of 1-methyl-ADD on the conversion of 4-androsten-3,17-dione to testosterone by the 17 beta-hydroxysteroid reductase enzyme in human testicular tissue. Our studies, presented in this manuscript, demonstrate that 1-methyl-ADD is a competitive inhibitor of 4-androsten-3,17-dione in its reduction to testosterone by the 17 beta-hydroxysteroid reductase enzyme in the human testis.
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Authors | M E Lombardo, S I Hakky, P B Hudson |
Journal | The Journal of steroid biochemistry and molecular biology
(J Steroid Biochem Mol Biol)
Vol. 44
Issue 3
Pg. 287-90
(Mar 1993)
ISSN: 0960-0760 [Print] England |
PMID | 8384873
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Testosterone
- Androstenedione
- atamestane
- 17-Hydroxysteroid Dehydrogenases
- 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))
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Topics |
- 17-Hydroxysteroid Dehydrogenases
(metabolism)
- Aged
- Androstenedione
(analogs & derivatives, metabolism, pharmacology)
- Binding, Competitive
- Humans
- In Vitro Techniques
- Male
- Middle Aged
- Orchiectomy
- Prostatic Neoplasms
(surgery)
- Testis
(drug effects, metabolism)
- Testosterone
(antagonists & inhibitors, biosynthesis)
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