[In vitro comparison of podophyllotoxin analogues; etoposide, teniposide and NK 611 using human lung cancer cell lines].

Abstract

In an attempt to predict the antitumor activity of a new podophyllotoxin analogue, NK 611, in the treatment of lung cancer, we compared the drug with etoposide and teniposide using four human small cell lung cancer (SCLC) cell lines, SBC-2, -3, -4, -7, and two non-small cell lung cancer cell lines, ABC-1, EBC-1. In terms of the fifty percent tumor growth inhibitory concentration (IC 50) determined by MTT assay, teniposide was most potent among the drugs. The degree of cross-resistance of each drug was investigated using an etoposide-resistant SCLC subline (SBC-3/ETP), an adriamycin-resistant subline (SBC-3/ADM 100), and a cisplatin-resistant subline (SBC-3/CDDP). As for relative resistant (the ratio of IC 50 for resistant subline to that for the parent subline), NK 611 was least cross-resistant to etoposide, adriamycin, and cisplatin among drugs tested. These results indicate that NK 611 may play a role in a salvage chemotherapy for patients with resistant SCLC.

• Authors: N Takigawa, T Ohnoshi, H Ueoka, K Kiura, T Moritaka, M Tabata, Y Segawa, T Shibayama, K Gemba, T Matsumura
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 20 Issue 4 Pg. 473-7 (Mar 1993) ISSN: 0385-0684 [Print] Japan
• PMID: 8383949 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antineoplastic Agents
• Tetrazolium Salts
• Thiazoles
• NK 611
• Etoposide
• Teniposide
• thiazolyl blue
• Podophyllotoxin

Topics

• Adenocarcinoma (pathology)
• Antineoplastic Agents (pharmacology)
• Carcinoma, Small Cell (pathology)
• Carcinoma, Squamous Cell (pathology)
• Cell Division (drug effects)
• Drug Resistance
• Drug Screening Assays, Antitumor
• Etoposide (pharmacology)
• Humans
• Lung Neoplasms (pathology)
• Podophyllotoxin (analogs & derivatives, pharmacology)
• Teniposide (pharmacology)
• Tetrazolium Salts (pharmacology)
• Thiazoles (pharmacology)
• Tumor Cells, Cultured