The relationship between collagen metabolism and temporomandibular joint osteoarthrosis in mice.

Abstract

The histologic changes in the temporo mandibular joint (TMJ) and the activity of serum collagenase-like (CL) peptidase and prolyl endopeptidase (PEP) were compared in mice with spontaneous osteoarthrosis (C57 black mouse/6 Silverberg (C57BL/6S) and control mice (C57 black mouse/6N (C57BL/6N) and ddY). The onset of osteoarthrosis of the TMJ in the C57BL/6S mice was noted at 12 weeks of age. Clefting in the chondrocyte layer was noted at 24 to 36 weeks of age; chondrocyte cluster and pannus at 36 to 60 weeks of age; and clefts deep in the bone and formation of osteophytes at 72 to 96 weeks of age. CL-peptidase and PEP activity significantly higher in C57BL/6S mice than in osteoarthrosis-free C57BL/6N and ddY mice. These changes occurred at an earlier age than the histologic changes. The findings suggest that these enzymes may play a significant role in the onset of osteoarthrosis in joints.

• Authors: Y Fukuoka, M Hagihara, T Nagatsu, T Kaneda
• Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 51 Issue 3 Pg. 288-91 (Mar 1993) ISSN: 0278-2391 [Print] United States
• PMID: 8383194 (Publication Type: Journal Article)

Chemical References

• Collagen
• Serine Endopeptidases
• Prolyl Oligopeptidases
• Microbial Collagenase

Topics

• Animals
• Cartilage, Articular (pathology)
• Collagen (metabolism)
• Female
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred Strains
• Microbial Collagenase (blood)
• Osteoarthritis (enzymology, pathology)
• Prolyl Oligopeptidases
• Serine Endopeptidases (blood)
• Synovial Membrane (pathology)
• Temporomandibular Joint Disorders (enzymology, pathology)
• Time Factors