Protection against bovine leukemia virus infection in two breeds of cattle.

Abstract

Calves of two breeds--Brown Latvian and Black and White, were immunized against bovine leukemia virus with an immunogen produced from short-term cultured blood lymphocytes of BLV-positive Brown Latvian cows. The immunogen contained the viral proteins gp51 and p24 as well as some cellular proteins. As determined by bioassay in sheep, it did not contain infective bovine leukemia virus. The calves were challenged by BLV-producing lymphocytes 2 weeks after the immunization procedure. Effective protection against BLV infection was induced by the tested immunogen in all Brown Latvian calves for 6 months and in 70% of the Black and White calves.

• Authors: R A Kukaine, L I Nagayeva, S V Chapenko, T N Iljinskaya, O I Bratsslavskaya, L A Vitolin, I K Yanchev, S Bozhkov, I I Alexandrov, R N Stefanova
• Journal: Comparative immunology, microbiology and infectious diseases (Comp Immunol Microbiol Infect Dis) Vol. 16 Issue 1 Pg. 63-71 (Jan 1993) ISSN: 0147-9571 [Print] England
• PMID: 8382592 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Viral
• Antigens, Viral
• Viral Proteins

Topics

• Animals
• Antibodies, Viral (blood)
• Antigens, Viral (administration & dosage, isolation & purification)
• Cattle
• Enzootic Bovine Leukosis (immunology, microbiology, prevention & control)
• Evaluation Studies as Topic
• Immunization
• Leukemia Virus, Bovine (immunology, isolation & purification)
• Lymphocyte Activation
• Lymphocytes (immunology, microbiology)
• Species Specificity
• Viral Proteins (administration & dosage, immunology, isolation & purification)