[The role of autocrine motility factor receptor in metastasis].

Abstract

Locomotion of tumor cells and its regulation are thought to be crucial for metastasis. Autocrine motility factor (AMF) is a cytokine which stimulates in vitro motility and in vivo lung-colonizing ability of tumor cells via a receptor, a cell surface glycoprotein of 78kD (gp78)-mediated signaling pathway. AMF induces gp78 internalization to intracellular tubulovesicles including lysosome and transport to the leading edge. The AMF-gp78 complex internalization from the cell surface is involved in control of cell motility during metastasis.

• Authors: H Watanabe, M Chigira, A Raz
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 20 Issue 3 Pg. 405-9 (Feb 1993) ISSN: 0385-0684 [Print] Japan
• PMID: 8382466 (Publication Type: Journal Article)

Chemical References

• Receptors, Cell Surface
• Receptors, Cytokine
• AMFR protein, human
• Receptors, Autocrine Motility Factor
• Ubiquitin-Protein Ligases
• Glucose-6-Phosphate Isomerase

Topics

• Cell Movement
• Fibrosarcoma (metabolism, pathology)
• Glucose-6-Phosphate Isomerase (metabolism)
• Humans
• Melanoma (metabolism, pathology)
• Neoplasm Metastasis (pathology)
• Receptors, Autocrine Motility Factor
• Receptors, Cell Surface (physiology)
• Receptors, Cytokine
• Tumor Cells, Cultured
• Ubiquitin-Protein Ligases