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Symptomatic Epstein-Barr virus infection and multiple sclerosis.

Abstract
In a case-control study of 214 patients with multiple sclerosis, recall of infectious mononucleosis in subjects seropositive for Epstein-Barr viral capsid antigen was associated with a relative risk of 2.9 (95% CI 1.1 to 7.2). Those who reported having infectious mononucleosis before the age of 18 years had a relative risk of multiple sclerosis of 7.9 (95% CI 1.7 to 37.9). The pathogenesis of multiple sclerosis may involve an age-dependent host response to Epstein-Barr virus infection.
AuthorsC N Martyn, M Cruddas, D A Compston
JournalJournal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 56 Issue 2 Pg. 167-8 (Feb 1993) ISSN: 0022-3050 [Print] England
PMID8382268 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Viral
  • HLA-DR2 Antigen
Topics
  • Antibodies, Viral (analysis)
  • Case-Control Studies
  • HLA-DR2 Antigen (analysis)
  • Herpesvirus 4, Human (immunology)
  • Humans
  • Infectious Mononucleosis (diagnosis, immunology)
  • London
  • Multiple Sclerosis (diagnosis, immunology)
  • Optic Neuritis (diagnosis, immunology)
  • Regression Analysis

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