The pharmacotherapy of obsessive-compulsive disorder.

Potent inhibitors of 5-hydroxytryptamine (5-HT) reuptake have clearly been established as the first-line pharmacotherapy for treatment of obsessive-compulsive disorder (OCD). Although a variety of tricyclic antidepressants and monoamine oxidase inhibitors have similar efficacy in the treatment of depression and panic disorder, potent blockade of 5-HT transport appears to be a prerequisite for effective treatment of OCD. Adding agents that enhance 5-HT neurotransmission to ongoing treatment in patients whose OCD is refractory to 5-HT reuptake inhibitors has not yielded impressive results. However, the addition of low-dose dopamine (DA) antagonists to the regimens of treatment-resistant patients appears to be a potentially useful strategy for the specific subgroup of OCD patients with a comorbid chronic tic disorder such as Tourette's syndrome. Because of the toxicity associated with neuroleptics, a time-limited trial of those agents, with reassessment at regular intervals, is indicated. Pharmacologic studies suggest that both the 5-HT and DA systems may be critical to the treatment and possibly the pathophysiology of OCD.
AuthorsC J McDougle, W K Goodman, L H Price
JournalPharmacopsychiatry (Pharmacopsychiatry) Vol. 26 Suppl 1 Pg. 24-9 (May 1993) ISSN: 0176-3679 [Print] GERMANY
PMID8378419 (Publication Type: Journal Article, Review)
Chemical References
  • Serotonin Uptake Inhibitors
  • Fluoxetine
  • 1-Naphthylamine
  • Clomipramine
  • Fluvoxamine
  • Sertraline
  • Desipramine
  • Buspirone
  • 1-Naphthylamine (analogs & derivatives, therapeutic use)
  • Buspirone (therapeutic use)
  • Clomipramine (therapeutic use)
  • Desipramine (therapeutic use)
  • Fluoxetine (therapeutic use)
  • Fluvoxamine (therapeutic use)
  • Humans
  • Obsessive-Compulsive Disorder (drug therapy)
  • Serotonin Uptake Inhibitors (therapeutic use)
  • Sertraline

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: