Abstract | OBJECTIVES: METHODS: RESULTS: Severe myelosuppression was observed at 150 mCi/m2 of 186Re in two evaluable patients. Other clinically significant toxicities included low-grade fever and transient skin rash. Hepatic enzyme elevation was seen in 12 of 17 patients, but was not clinically significant. No chronic enteric toxicity was observed. Decreased tumor size was demonstrated by repeat operation in four of seven patients with disease measuring less than 1 cm at the time of treatment (four of 17 total). All four responders had serum CA 125 levels of 35 U/mL or less at the time of treatment and had received only one regimen of chemotherapy. CONCLUSION: This immunoconjugate can be administered intraperitoneally with acceptable toxicity and produces objective responses after a single dose in patients with minimal objective disease.
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Authors | A J Jacobs, M Fer, F M Su, H Breitz, J Thompson, H Goodgold, J Cain, J Heaps, P Weiden |
Journal | Obstetrics and gynecology
(Obstet Gynecol)
Vol. 82
Issue 4 Pt 1
Pg. 586-93
(Oct 1993)
ISSN: 0029-7844 [Print] United States |
PMID | 8377986
(Publication Type: Clinical Trial, Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Carcinoma
(drug therapy, radiotherapy)
- Combined Modality Therapy
- Female
- Follow-Up Studies
- Humans
- Injections, Intraperitoneal
- Middle Aged
- Ovarian Neoplasms
(drug therapy, radiotherapy)
- Radioimmunotherapy
(adverse effects)
- Radioisotopes
(administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
- Rhenium
(administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
- Tissue Distribution
- Treatment Outcome
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