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Antihyperlipidemic effect of flavonoids from Pterocarpus marsupium.

Abstract
Serum lipid levels in rats with hyperlipidemia induced by diet as well as by Triton were determined after oral administration of EtOAc extract of Pterocarpus marsupium heartwood and its flavonoid constituents, marsupsin [1], pterosupin [2], and liquiritigenin [3]. Administration of EtOAc extract for 14 consecutive days produced a significant reduction of serum triglyceride, total cholesterol, and LDL- and VLDL-cholesterol levels without any significant effect on the level of HDL-cholesterol. Liquiritigenin and pterosupin were able to effect a significant fall in serum cholesterol, LDL-cholesterol, and atherogenic index, pterosupin being additionally effective in lowering serum triglyceride.
AuthorsM A Jahromi, A B Ray
JournalJournal of natural products (J Nat Prod) Vol. 56 Issue 7 Pg. 989-94 (Jul 1993) ISSN: 0163-3864 [Print] United States
PMID8377021 (Publication Type: Journal Article)
Chemical References
  • Anticholesteremic Agents
  • Benzofurans
  • Cresols
  • Flavanones
  • Flavonoids
  • Glucosides
  • Hypolipidemic Agents
  • Lipids
  • Phenols
  • Plant Extracts
  • Triglycerides
  • Polyethylene Glycols
  • pterosupin
  • marsupsin
  • Cholesterol
  • liquiritigenin
Topics
  • Animals
  • Anticholesteremic Agents (pharmacology)
  • Benzofurans (isolation & purification, pharmacology)
  • Cholesterol (blood)
  • Cresols (isolation & purification, pharmacology)
  • Diet
  • Flavanones
  • Flavonoids (isolation & purification, pharmacology)
  • Glucosides (isolation & purification, pharmacology)
  • Hyperlipidemias (blood, chemically induced, drug therapy)
  • Hypolipidemic Agents (pharmacology)
  • Lipids (blood)
  • Male
  • Phenols (isolation & purification, pharmacology)
  • Plant Extracts (analysis, pharmacology)
  • Plants (chemistry)
  • Polyethylene Glycols
  • Rats
  • Triglycerides (blood)

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