Urinary p-tyramine in hereditary tyrosinemia: II. Origin of urinary p-tyramine.

Abstract

1. A patient with hereditary tyrosinemia (tyrosinosis) was given oral loads of p-tyramine and tyrosine with and without medication (neomycin) to investigate the respective roles of intestinal bacteria and tissues in accounting for the origin of urinary p-tyramine. 2. The excretion of a high circulating level of p-tyramine following an oral load of p-tyramine in a patient with hereditary tyrosinemia (tyrosinosis) was as conjugated p-hydroxyphenylacetic acid (p-HPAA) and conjugated p-tyramine. 3. Both intestinal bacterial activity and tissue decarboxylation appeared to account for urinary p-tyramine in this patient following an oral load of tyrosine. 4. Sterilization of the gut by oral neomycin and a second load of oral tyrosine further supported a predominate role for tissue decarboxylation in the origin of urinary p-tyramine. 5. The data suggested that a major route of tyrosine metabolism in man may be via tissue decarboxylation of tyrosine.

• Authors: G N Hoag, A Hill, W Zaleski
• Journal: Clinical biochemistry (Clin Biochem) Vol. 10 Issue 1 Pg. 26-8 (Feb 1977) ISSN: 0009-9120 [Print] United States
• PMID: 837523 (Publication Type: Journal Article)

Chemical References

• Tyrosine
• Oxygenases
• 4-Hydroxyphenylpyruvate Dioxygenase
• Neomycin
• Tyramine

Topics

• 4-Hydroxyphenylpyruvate Dioxygenase (deficiency)
• Administration, Oral
• Adolescent
• Amino Acid Metabolism, Inborn Errors (urine)
• Diet
• Female
• Humans
• Neomycin (therapeutic use)
• Oxygenases (deficiency)
• Tyramine (administration & dosage, metabolism, urine)
• Tyrosine (metabolism)