[A new trial of plachitin particles for intraarterial chemoembolization therapy in rabbit].

Abstract

Plachitin, which is reconstituted by the combination of CDDP and chitin, has been reported to have a slow releasing property of CDDP and an antitumor effect. The antitumor effect and pharmacokinetics of Plachitin for intraarterial chemoembolization therapy were studied in rabbits using VX2 tumor inoculated in the hind limb. One gram of Plachitin contained 300 mg CDDP, and the form of Plachitin was modified into particles (about 50 microns in diameter). Plachitin was injected into the femoral artery. The study was carried out in four groups. The tumor growth ratio was significantly lower in the Plachitin group than in the CDDP, chitin, and control groups (p < 0.05). Tumor regression was noticed only in the Plachitin group. The tumor platinum (Pt.) level was higher than the serum Pt. level for 5 days after Plachitin injection. From the above results it can be concluded that Plachitin particles released CDDP slowly around the tumor and the tumor growth was suppressed by the additive effect of CDDP and embolization. Plachitin was considered a useful agent for chemoembolization therapy for the cancer patients.

• Authors: H Tabara, H Matsuura, M Tachibana, H Yoshimura, T Kotoh, D K Dhar, N Nagasue, T Nakamura, K Kifune, R Tsurutani
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 20 Issue 11 Pg. 1582-5 (Aug 1993) ISSN: 0385-0684 [Print] Japan
• PMID: 8373224 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Delayed-Action Preparations
• Drug Combinations
• plachitin
• Chitin
• Cisplatin

Topics

• Animals
• Chemoembolization, Therapeutic
• Chitin (administration & dosage, pharmacokinetics)
• Cisplatin (administration & dosage, pharmacokinetics)
• Delayed-Action Preparations
• Drug Combinations
• Liver Neoplasms, Experimental (metabolism, pathology, therapy)
• Rabbits