[Ranitidine therapeutically effective in functional dyspepsia with reflux-like symptoms].

Abstract

OBJECTIVE:

To investigate the effect of ranitidine in patients with functional dyspepsia according to different subgroups.

SETTING:

University Hospital Utrecht, department of gastroenterology.

DESIGN:

Prospective double blind cross-over study.

METHOD:

Thirty patients with chronic upper abdominal symptoms were included, without somatic cause was found at gastroscopy (no Helicobacter pylori), ultrasonography and blood tests. The mean symptom score of: nausea, vomiting, retrosternal pain, epigastric pain, heartburn, bloating, belching, and early satiety was > or = 2. The patients recorded severity and frequency of the symptoms in a diary. The same diary was used to score the symptoms during treatment with ranitidine (2 dd 150 mg) or placebo, each for 2 weeks with a wash out period of 3 days. 29 patients scored correctly.

RESULTS:

13 (43%) patients had dysmotility-like dyspepsia, 5 (17%) reflux-like dyspepsia, and 11 (40%) non-specific dyspepsia (i.e. a combination of dysmotility-like, reflux-like or ulcer-like symptoms). Ranitidine significantly improved the severity of heartburn after two weeks of treatment, as compared to placebo (p = 0.035), notably in the patients with reflux-like dyspepsia. Because of a carry-over effect analysis of the symptoms 'belching' and 'early satiety' was not possible.

CONCLUSION:

Within the group of patients with functional dyspepsia a subgroup of reflux-like dyspepsia patients can be identified that responds well to ranitidine.

• Authors: H J Jebbink, A J Smout, G P van Berge Henegouwen
• Journal: Nederlands tijdschrift voor geneeskunde (Ned Tijdschr Geneeskd) Vol. 137 Issue 35 Pg. 1772-5 (Aug 28 1993) ISSN: 0028-2162 [Print] Netherlands
• Vernacular Title: Ranitidine vooral werkzaam bij functionele dyspepsie met klachten passend bij refluxziekten.
• PMID: 8371822 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Ranitidine

Topics

• Adult
• Double-Blind Method
• Duodenogastric Reflux (physiopathology)
• Dyspepsia (drug therapy, physiopathology)
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• Ranitidine (therapeutic use)