Abstract |
Bullatacin, a compound isolated from plants of the Annonaceae, and its analogues show in vivo potential as antitumor agents based on their efficacy in normal mice bearing L1210 murine leukemia and athymic mice bearing A2780 conventional ovarian cancer xenografts. These compounds also have interesting potential as insecticides and inhibit respiration in insect-derived Sf9 cells with high potency. Their toxicity in both cases probably arises from their strong inhibition of mitochondrial electron transport with a specific action at complex I.
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Authors | K I Ahammadsahib, R M Hollingworth, J P McGovren, Y H Hui, J L McLaughlin |
Journal | Life sciences
(Life Sci)
Vol. 53
Issue 14
Pg. 1113-20
( 1993)
ISSN: 0024-3205 [Print] Netherlands |
PMID | 8371627
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Furans
- Insecticides
- bullatacin
- bullatacinone
- bullatalicin
- NAD(P)H Dehydrogenase (Quinone)
- Chymotrypsin
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Cattle
- Chymotrypsin
(metabolism)
- Furans
(pharmacology)
- In Vitro Techniques
- Insecticides
(pharmacology)
- Male
- Mice
- Mitochondria
(drug effects)
- Moths
- NAD(P)H Dehydrogenase (Quinone)
(drug effects)
- Oxygen Consumption
(drug effects)
- Plants
- Rats
- Rats, Sprague-Dawley
- Stereoisomerism
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