Comparison of ondansetron with customary treatment in the prophylaxis of nausea and emesis induced by non-cisplatin containing chemotherapy.

Abstract

One hundred cancer patients receiving non-cisplatin containing chemotherapy were entered in a prospective study in which the efficacy of ondansetron was compared with standard antiemetic treatments in the prophylaxis of nausea and emesis. During the first 24 h, 77% of patients on ondansetron reported complete control of emesis compared with 56% of those on customary treatments (p = 0.03). However, no statistically significant difference was observed between ondansetron and customary treatments in control of delayed emesis on days 2-5. Nor was any statistically significant difference seen between ondansetron and customary treatments in preventing acute or delayed nausea.

• Authors: I T Jantunen, M K Flander, M I Heikkinen, T A Kuoppala, L Teerenhovi, V V Kataja
• Journal: Acta oncologica (Stockholm, Sweden) (Acta Oncol) Vol. 32 Issue 4 Pg. 413-5 ( 1993) ISSN: 0284-186X [Print] England
• PMID: 8369129 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Antiemetics
• Ondansetron
• Cisplatin

Topics

• Adult
• Aged
• Antiemetics (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Cisplatin (adverse effects, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Nausea (prevention & control)
• Neoplasms (drug therapy)
• Ondansetron (therapeutic use)
• Prospective Studies
• Vomiting (prevention & control)