Abstract |
We have evaluated the effect of a novel anti-rheumatic drug, cis-2-(4-chlorophenyl)-4,5-diphenyl-2-imidazoline hydrochloride (TA-383), on type II collagen (CII)-induced arthritis in DBA/1J mice. Treatment with TA-383 (0.4 mg/kg/day) from the day of immunization with CII strongly suppressed the arthritic responses. Increased serum interleukin 6 (IL-6) level was lowered in parallel with the effect. Effect of TA-383 on IL-6 production was examined in vitro. TA-383 inhibited the production of IL-6 by murine synovial fibroblasts stimulated with recombinant interleukin 1 (IL-1) beta in a dose-dependent manner (0.1-10 microM). Neither the general protein synthesis nor the expression of type I IL-1 receptor was affected by TA-383. The results show that TA-383 possesses an inhibitory activity on IL-6 generation and suggest that the effect may partly contribute to the anti-arthritic effect of TA-383.
|
Authors | T Sugita, M Ueno, O Furukawa, T Murakami, I Takata, T Tosa |
Journal | International journal of immunopharmacology
(Int J Immunopharmacol)
Vol. 15
Issue 4
Pg. 515-9
(May 1993)
ISSN: 0192-0561 [Print] England |
PMID | 8365826
(Publication Type: Journal Article)
|
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Imidazoles
- Interleukin-6
- 2-(4-chlorophenyl)-4,5-diphenyl-2-imidazoline hydrochloride
- Collagen
|
Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology)
- Arthritis
(drug therapy, etiology, immunology)
- Autoimmune Diseases
(drug therapy, etiology, immunology)
- Collagen
(immunology)
- Fibroblasts
(immunology)
- Imidazoles
(pharmacology)
- In Vitro Techniques
- Interleukin-6
(biosynthesis)
- Male
- Mice
- Mice, Inbred DBA
- Synovial Membrane
(immunology)
|