Treatment of cryptococcosis with liposomal amphotericin B (AmBisome) in 23 patients with AIDS.

Abstract

OBJECTIVE:

To determine the safety and efficacy of liposomal amphotericin B (AmBisome) in the primary treatment of AIDS-associated cryptococcosis.

DESIGN:

A Phase II, multicentre, European, non-comparative, open study to assess the use of AmBisome in 23 patients (26 enrolments) with cryptococcosis. Dose requirements, mycological response and toxicity were documented.

SETTING:

Hospital-based HIV units.

PATIENTS:

Twenty-three HIV-1-seropositive patients.

RESULTS:

Drug toxicity, assessed in 25 enrolments, was well-tolerated with little renal, hepatic or haematological toxicity. Eighteen out of 23 (78%) enrolments responded clinically. Nineteen enrolments had cryptococcal meningitis: sterilization of spinal fluid was achieved in 12 out of the 18 (67%) who were mycologically evaluable. Fourteen out of the 19 (74%) responded clinically.

CONCLUSION:

AmBisome is well-tolerated and may be an effective formulation in the treatment of cryptococcosis.

• Authors: R J Coker, M Viviani, B G Gazzard, B Du Pont, H D Pohle, S M Murphy, J Atouguia, J L Champalimaud, J R Harris
• Journal: AIDS (London, England) (AIDS) Vol. 7 Issue 6 Pg. 829-35 (Jun 1993) ISSN: 0269-9370 [Print] England
• PMID: 8363759 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Carriers
• Liposomes
• Amphotericin B

Topics

• AIDS-Related Opportunistic Infections (drug therapy)
• Acquired Immunodeficiency Syndrome (complications, mortality)
• Adult
• Amphotericin B (administration & dosage, adverse effects, therapeutic use)
• Body Fluids (microbiology)
• Cryptococcosis (complications, drug therapy)
• Cryptococcus neoformans (isolation & purification)
• Drug Carriers
• HIV-1
• Humans
• Leukocyte Count
• Life Tables
• Liposomes
• Male
• Meningitis, Cryptococcal (cerebrospinal fluid, complications, drug therapy)
• Middle Aged
• Survival Analysis