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Evaluation of new therapy for eradication of H. pylori infection in nude mouse model.

AbstractOBJECTIVES:
developing a new therapy for eradication of H. pylori by using the nude mouse model.
METHODS:
By quantifying the number of colonies of Helicobacter pylori and the score of H. pylori-associated gastritis from the gastric tissue following different drug regimens in inoculated nude mice, we evaluated the effectiveness of each regimen, including a new drug, plaunotol. Drugs were administered daily for a 1-wk period, beginning 4 wk after inoculation.
RESULTS:
In the examination after therapy, the number of colonies of H. pylori and the score of gastritis in the triple-therapy group were significantly lower than in any of the singly- and dual-drug groups or control group from 5 wk to the end of the study after inoculation. Inflammation of the stomach was less apparent in the treatment groups than in the control group.
CONCLUSION:
With the nude mouse model, we quantitatively demonstrated that the new triple therapy is the most effective therapy for eradication of H. pylori.
AuthorsM Karita, Q Li, K Okita
JournalThe American journal of gastroenterology (Am J Gastroenterol) Vol. 88 Issue 9 Pg. 1366-72 (Sep 1993) ISSN: 0002-9270 [Print] United States
PMID8362832 (Publication Type: Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Diterpenes
  • Fatty Alcohols
  • Metronidazole
  • Amoxicillin
  • plaunotol
Topics
  • Amoxicillin (therapeutic use)
  • Animals
  • Anti-Ulcer Agents (therapeutic use)
  • Diterpenes
  • Drug Evaluation, Preclinical
  • Drug Therapy, Combination
  • Fatty Alcohols (therapeutic use)
  • Gastric Mucosa (pathology)
  • Gastritis (drug therapy, microbiology, pathology)
  • Helicobacter Infections (drug therapy, microbiology, pathology)
  • Helicobacter pylori (growth & development)
  • Male
  • Metronidazole (therapeutic use)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude

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