Abstract | OBJECTIVES: developing a new therapy for eradication of H. pylori by using the nude mouse model. METHODS: By quantifying the number of colonies of Helicobacter pylori and the score of H. pylori-associated gastritis from the gastric tissue following different drug regimens in inoculated nude mice, we evaluated the effectiveness of each regimen, including a new drug, plaunotol. Drugs were administered daily for a 1-wk period, beginning 4 wk after inoculation. RESULTS: In the examination after therapy, the number of colonies of H. pylori and the score of gastritis in the triple-therapy group were significantly lower than in any of the singly- and dual- drug groups or control group from 5 wk to the end of the study after inoculation. Inflammation of the stomach was less apparent in the treatment groups than in the control group. CONCLUSION: With the nude mouse model, we quantitatively demonstrated that the new triple therapy is the most effective therapy for eradication of H. pylori.
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Authors | M Karita, Q Li, K Okita |
Journal | The American journal of gastroenterology
(Am J Gastroenterol)
Vol. 88
Issue 9
Pg. 1366-72
(Sep 1993)
ISSN: 0002-9270 [Print] United States |
PMID | 8362832
(Publication Type: Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Diterpenes
- Fatty Alcohols
- Metronidazole
- Amoxicillin
- plaunotol
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Topics |
- Amoxicillin
(therapeutic use)
- Animals
- Anti-Ulcer Agents
(therapeutic use)
- Diterpenes
- Drug Evaluation, Preclinical
- Drug Therapy, Combination
- Fatty Alcohols
(therapeutic use)
- Gastric Mucosa
(pathology)
- Gastritis
(drug therapy, microbiology, pathology)
- Helicobacter Infections
(drug therapy, microbiology, pathology)
- Helicobacter pylori
(growth & development)
- Male
- Metronidazole
(therapeutic use)
- Mice
- Mice, Inbred BALB C
- Mice, Nude
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