Inhibitory effects of the 5-HT1A agonists, 5-hydroxy- and 5-methoxy-(3-di-n-propylamino)chroman, on female lordosis behavior.

Abstract

Sexually receptive, intact, proestrous rats were infused bilaterally into the ventromedial nucleus of the hypothalamus with one of several serotonin (5-HT) agonists and with the endogenous ligand, 5-HT. Serotonin (2000 ng) and the 5-HT1A agonists, 8-hydroxy-2-(di-n-propylamino)tetralin [8-OH-DPAT (200 ng)], 5-methoxy-3-(di-n-propylamino)chroman [5-MEO-DPAC (200-2000 ng)] and 5-hydroxy-3-(N-di-n-propylamino)chroman [5-OH-DPAC (200-2000 ng)] inhibited female lordosis behavior within 10 min of the infusion. The rank order of the effectiveness of these compounds was 8-OH-DPAT > 5-OH-DPAC > or = 5-MEO-DPAC > 5-HT. The nonselective 5-HT agonist, 1-(m-trifluoromethyl) piperazine [TFMPP (2000 ng)], did not reduce lordosis behavior. In addition to their reduction of lordosis behavior, the 5-HT1A agonists elicited resistive behavior toward the male's attempts to mount. There were minimal effects of the 5-HT1A agonists on either quality of the lordosis reflex or on proceptivity. However, rats pretreated with TFMPP and infused with 8-OH-DPAT 1 hr later, did show a transient suppression of lordosis quality. These results provide further evidence that the ventromedial nucleus of the hypothalamus contains 5-HT1A sites, the activation of which reduces lordosis behavior in regularly cycling, proestrous rats.

• Authors: L Uphouse, M Caldarola-Pastuszka, N Moore
• Journal: Neuropharmacology (Neuropharmacology) Vol. 32 Issue 7 Pg. 641-51 (Jul 1993) ISSN: 0028-3908 [Print] England
• PMID: 8361579 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Chromans
• Piperazines
• Serotonin Receptor Agonists
• 3-propylamino-5-hydroxychroman
• 5-methoxy-3-(di-n-propylamino)chroman
• 1-(3-trifluoromethylphenyl)piperazine
• Serotonin
• 8-Hydroxy-2-(di-n-propylamino)tetralin

Topics

• 8-Hydroxy-2-(di-n-propylamino)tetralin (pharmacology)
• Animals
• Chromans (administration & dosage, pharmacology)
• Female
• Injections
• Male
• Piperazines (pharmacology)
• Posture
• Proestrus (physiology)
• Rats
• Rats, Inbred F344
• Serotonin (pharmacology)
• Serotonin Receptor Agonists (administration & dosage, pharmacology)
• Sexual Behavior, Animal (drug effects)
• Ventromedial Hypothalamic Nucleus (anatomy & histology)