Abstract |
Twenty-six families with recurrent staphylococcal infections were treated with either mupirocin nasal ointment (group M) or chlorhexidine neomycin ( Naseptin) cream (group N) to the anterior nares, each combined with chlorhexidine soap for washing and chlorhexidine powder applied to other possible carriage sites. Patients receiving mupirocin following failure with chlorhexidine/ neomycin (group M/N) were also treated. Treatment was given for seven days to 99 patients, 32 index (infected) patients and 67 family members. Follow-up swabs were collected by a study nurse 8, 14, 28, and 91 days after starting treatment. The carriage of Staphylococcus aureus in the anterior nares was 67%, in the axillae 22%, in the groin 23%, and perianal 19%. The carriage rates in the index patients was higher than family members, in all sites. The eradication of S. aureus from the nasal carriage site after therapy at 8 days was 95% in group M, 85% in group M/N and 61% in group N. Recolonization during the follow-up period was much less in those treated with mupirocin: 57% of patients in group M and 42% in group M/N were not carriers at 91 days, whereas 89% of patients group N were again colonized. Assessment clinically and in terms of prevention of further infective lesions showed that there was a higher response to mupirocin than to chlorhexidine/ neomycin. Mupirocin nasal is a successful therapy for removing nasal carriage of S. aureus and has a prolonged effect on recolonization.
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Authors | D A Leigh, G Joy |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 31
Issue 6
Pg. 909-17
(Jun 1993)
ISSN: 0305-7453 [Print] England |
PMID | 8360128
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents, Local
- Drug Combinations
- Naseptin
- Ointments
- Mupirocin
- Neomycin
- Chlorhexidine
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Topics |
- Anti-Infective Agents, Local
(therapeutic use)
- Carrier State
(drug therapy)
- Chlorhexidine
(administration & dosage, therapeutic use)
- Drug Combinations
- Family Health
- Humans
- Mupirocin
(administration & dosage, therapeutic use)
- Neomycin
(administration & dosage, therapeutic use)
- Nose
(microbiology)
- Ointments
- Recurrence
- Staphylococcal Infections
(drug therapy, genetics)
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