Clinical significance of vesicoureteral reflux after kidney transplantation.

Abstract

In this study 103 out of our 125 CsA-treated patients who received between January 1985 and December 1989 a first cadaver kidney transplant that functioned for at least one year were studied with voiding cystography (VC) for vesicoureteral reflux (VUR). All patients had an external uretero-neo-cystostomy. VUR occurred in 89 (86.4%) patients. Patients were grouped according to VUR: absence of VUR (group 0), VUR grade I-II (group 1-2), and VUR grade III (group 3). The 3 groups were comparable for male/female ratio, cause of renal failure, cause of donor death, recipient and dialytic age, immunosuppressive therapy, follow-up, time of VC performance after transplantation. At 6 months and 1, 2, 3, 4, and 5 years after transplantation graft function, number of rejection episodes, and number of urinary tract infections (UTIs) were similar in the 3 groups. In groups 1-2 and 3 hypertension was more frequent than in group 0 and occurred even after the 6th month (whereas this did not happen in group 0), but the differences between the 3 groups were not significant. However, when only the 13 patients who were followed for 5 years were considered, the prevalence of hypertension after 5 years was significantly higher in groups 1-2 and 3 (both 100.0%) than in group 0 (33.3%) (chi-square = 7.88; p < 0.02). Finally, 4.5% of patients with VUR and no patients without VUR had septic episodes linked to UTIs, but the difference was not significant.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: S Mastrosimone, G Pignata, M C Maresca, G Calconi, A Rabassini, R Butini, A Fandella, G Di Falco, G Chiara, C Caldato
• Journal: Clinical nephrology (Clin Nephrol) Vol. 40 Issue 1 Pg. 38-45 (Jul 1993) ISSN: 0301-0430 [Print] Germany
• PMID: 8358874 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Cyclosporine

Topics

• Adult
• Cadaver
• Cyclosporine (therapeutic use)
• Female
• Follow-Up Studies
• Graft Rejection (epidemiology)
• Humans
• Hypertension (epidemiology)
• Kidney Transplantation (physiology)
• Male
• Prevalence
• Prognosis
• Time Factors
• Urinary Tract Infections (epidemiology)
• Vesico-Ureteral Reflux (diagnosis, epidemiology, etiology)